Thermodynamics of DNA microarrays

Tom 80 / 2008

Enrico Carlon Banach Center Publications 80 (2008), 229-233 MSC: Primary 92E20; Secondary 80A10. DOI: 10.4064/bc80-0-13


DNA microarrays have been widely used in molecular biology laboratories. The main current application of these devices is the determination of the gene expression level for thousands of genes simultaneously. Here we review a recently introduced physical model for hybridization (i.e. the binding of complementary DNA strands) in Affymetrix arrays and compare it to experimental results. The experimental data follow rather well the microscopic model and the approach offers several advantages compared to traditional methods of microarray data analysis.


  • Enrico CarlonInterdisciplinary Research Institute of Lille
    École Polytechnique Universitaire de Lille (Polytech'Lille)
    Cité Scientifique
    F-59652 Villeneuve d'Ascq, France

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